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Special warnings about this medication
Your doctor should check your progress at regular visits, especially during the first few months of treatment with this medicine. The amount of Zyban you take may have to be changed often to meet the
needs of your condition and to help avoid unwanted effects.
Do not take Zyban within 14 days of taking an MAO inhibitor.
Zyban is sold under different brand names for different uses.
If you are already taking medicine for mental depression or to help you stop smoking, discuss this with your health care professional before taking Zyban. It is very important that you receive only o
ne prescription for Zyban at a time.
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Proper Use of This Medicine
Treatment with this drug begins while you are still smoking. Zyban needs about a week to reach an effective level in your body; so to improve your chance of success, you should not attempt to quit unt
il the second week of treatment. Set a firm date for quitting. If you are still smoking after that date, your odds of breaking the habit will be worse. You should keep taking Zyban for 7 to 12 weeks.
You can use nicotine patches along with Zyban. However, combining the two treatments can raise your blood pressure, so it's important to tell your doctor if you plan to use both. Do not smok
e while using a patch, because too much nicotine can cause serious side effects.
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Possible Side Effect
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your
doctor as soon as possible if any of the following side effects occur:
More common
- Agitation; anxiety
Less common
- Buzzing or ringing in ears; headache (severe); sk
in rash, hives, or itching
Rare
- Confusion; extreme distrust; fainting; false beliefs that cannot be changed by facts; hallucinations (seeing, hearing, or feeling things that are
not there); seizures (convulsions), especially with higher doses; trouble in concentrating
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What special precautions should I follow?
A variety of conditions can predispose you to seizures, including:
- Prior head injuries
- Prior seizures
- Central nervous system tumors
- Cirrhosis of the liver
- Too m
uch alcohol
- Abrupt withdrawal from alcohol, tranquilizers, or sedatives
- Addiction to narcotics or cocaine
- Use of over-the-counter stimulants or diet pills
- Use of diabetes m
edications
- Use of antidepressants, major tranquilizers, steroids, or theophylline
If any of these apply to you, use Zyban with care. If you do have a seizure while taking Zyban, stop
taking the drug and never take it again.
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What Is It
Zyban was introduced in the USA in 1985 and was withdrawn in 1986 because of an unacceptable incidence of seizures. In 1989 it was reintroduced in the USA (maximum dose of 450 mg daily). Zyban was fir
st approved in Canada in 1998 as an SR twice-daily formulation. In one RCT buproprion SR, 150 mg daily and 150 mg BID, were similar and more effective than placebo based on physician rated scores of d
epression at 8 weeks.8 In 2 RCTs Zyban (150-400 mg/day) was similar in effectiveness to sertraline (50-200 mg/day) at 8 weeks, but the incidence of satisfaction with sexual functioning was less with s
ertraline (63%) than buproprion (79%) and placebo (78%). 9, 10
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